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BMC Medical Genetics

, 15:5

Genetic epidemiology and genetic associations

Abstract

BackgroundTuberculosis is a major infectious disease and functional studies have provided evidence that both the chemokine MIP-1α and its receptor CCR5 play a role in susceptibility to TB. Thus by measuring copy number variation of CCL3L1, one of the genes that encode MIP-1α, and genotyping a functional promoter polymorphism -2459A > G in CCR5 rs1799987 we investigate the influence of MIP-1α and CCR5, independently and combined, in susceptibility to clinically active TB in three populations, a Peruvian population n = 1132, a !Xhosa population n = 605 and a South African Coloured population n = 221. The three populations include patients with clinically diagnosed pulmonary TB, as well as other, less prevalent forms of extrapulmonary TB.

Methods and resultsCopy number of CCL3L1 was measured using the paralogue ratio test and exhibited ranges between 0–6 copies per diploid genome pdg in Peru, between 0–12 pdg in !Xhosa samples and between 0–10 pdg in South African Coloured samples. The CCR5 promoter polymorphism was observed to differ significantly in allele frequency between populations *A; Peru f = 0.67, !Xhosa f = 0.38, Coloured f = 0.48.

ConclusionsThe case–control association studies performed however find, surprisingly, no evidence for an influence of variation in genes coding for MIP-1α or CCR5 individually or together in susceptibility to clinically active TB in these populations.

KeywordsCCL3L1 Mycobacterium tuberculosis Association CCR5 MIP-1α Electronic supplementary materialThe online version of this article doi:10.1186-1471-2350-15-5 contains supplementary material, which is available to authorized users.

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