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BMC Medical Genetics

, 15:8

Bacterial and fungal diseases

Abstract

BackgroundPrevious epidemiological studies have presented conflicting evidence regarding associations between interleukin-1 IL-1 polymorphisms and sepsis susceptibility. We have performed a meta-analysis to evaluate possible associations between IL-1 polymorphisms and sepsis risk.

MethodsEligible literature was retrieved from PubMed, Embase and Web of Knowledge databases until Jun 15, 2013. The pooled odds ratio OR and 95% confidence interval CI were calculated using random-effects model in the overall and subgroup analysis based on ethnicity, sepsis severity and quality score.

ResultsEighteen studies addressing five IL-1 polymorphisms were included in this meta-analysis. For IL-1A-889 rs1800587 polymorphism, significant association was observed in overall comparison for allelic effect OR = 1.47, 95% CI = 1.01-2.13, P = 0.04. There were no significant associations between either IL-1B-511 rs16944 or IL-1B-31 rs1143627 and sepsis susceptibility in overall or subgroup analyses. For IL-1B + 3594 rs143634 polymorphism, genotype TT decreased sepsis risk in overall analysis OR = 0.59, 95% CI = 0.36-0.97, P = 0.04, as well as in Caucasian OR = 0.57, 95% CI = 0.34-0.95, P = 0.03 and sepsis OR = 0.55, 95% CI = 0.31-0.97, P = 0.04 subgroup analysis. For IL-1RN VNTR polymorphism, significant association was observed in overall comparison for allelic effect OR = 1.40, 95% CI = 1.01-1.95, P = 0.04. Furthermore, the effect sizes of IL-1RN VNTR on sepsis risk increased with disease severity septic shock OR > severe sepsis OR > sepsis OR.

ConclusionsOur meta-analysis indicated that IL-1A-889, IL-1B + 3954 and IL-1RN VNTR might be associated with sepsis susceptibility. However, further studies with larger sample sizes and from homogenous populations would be necessary to validate these findings.

KeywordsSepsis IL-1 Polymorphism Meta-analysis AbbreviationsIL-1Interleukin-1

IL-1RNInterleukin-1 receptor antagonist

VNTRVariable number of tandem repeats

OROdds ratio

CIConfidence interval

HWEHardy-Weinberg equilibrium

NOSNewcastle-Ottawa quality assessment scale

PCR-RFLPPolymerase chain reaction-restriction fragment length polymorphism.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2350-15-8 contains supplementary material, which is available to authorized users.

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Autor: An-qiang Zhang - Wei Pan - Jun-wei Gao - Cai-li Yue - Ling Zeng - Wei Gu - Jian-xin Jiang

Fuente: https://link.springer.com/







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