CYP1A1 Ile462Val Polymorphism as a Risk Factor in Cervical Cancer Development in the Polish PopulationReportar como inadecuado




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Molecular Diagnosis and Therapy

, Volume 18, Issue 4, pp 445–450

First Online: 14 March 2014

Abstract

Background and objectiveThere are inconsistent data of the cytochrome P450 1A1 CYP1A1 Ile462Val rs1048943 single nuclear polymorphism SNP as a genetic susceptibility factor for cervical cancer in various populations. Moreover, little is known about the interaction of this SNP with other risk factors, including contraceptive use, postmenopausal status, parity, and tobacco smoking.

MethodsPolymerase chain reaction-restriction fragment length polymorphism was used to study the prevalence of the CYP1A1 Ile462Val SNP in women with cervical cancer n = 456 and controls n = 495.

ResultsLogistic regression analysis adjusting for age, parity, oral contraceptive use, tobacco smoking, and menopausal status demonstrated that that the CYP1A1 Ile-Val polymorphism was not associated with an increased risk of cervical cancer in all patients. The adjusted odds ratio OR for patients with the Ile-Val genotype vs. Ile-Ile genotype was 1.539 95 % confidence interval CI 0.932–2.541, p = 0.091. However, an increase in cervical cancer risk was seen among patients with a positive history of tobacco smoking and parity. The adjusted OR for positive history of tobacco smoking with the Ile-Val vs. Ile-Ile genotypes was 2.978 95 % CI 1.382–6.418, p = 0.0052. The adjusted OR for parity with the Ile-Val vs. Ile-Ile genotype was 1.739 95 % CI 1.006–3.009, p = 0.0472.

ConclusionOur genetic study suggests that the CYP1A1 Ile462Val SNP may be a risk factor for cervical cancer among patients with a positive history of tobacco smoking and parity.

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Autor: Andrzej Roszak - Margarita Lianeri - Anna Sowińska - Pawel P. Jagodziński

Fuente: https://link.springer.com/



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