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BMC Medical Genetics

, 15:92

Genetic epidemiology and genetic associations


BackgroundInflammation is a response of body tissues to injury or irritation. Small RNAs, such as miR-146a and miR-499, participate in various processes of tumorigenesis. A recent study indicates that inflammation and abnormal immune responses may promote malignant progression in cancer development, indicating that inflammation-related polymorphisms such as miR-146a rs2910164 and miR-499 rs3746444 are crucial. However, studies on the association of these two polymorphisms with hepatocellular carcinoma HCC are inconclusive and inconsistent. We aimed at accessing the combined result of reported studies and make a more precise estimate of the relationship.

MethodsMeta-analysis was performed on the associations between the miR-146a rs2910164 C > G and miR-499 rs3746444 T > C polymorphisms and hepatocellular carcinoma, using: allele contrast, dominant, and recessive models. A total of 12 studies8 on miR-146a rs2910164 and 4 on miR-499 rs3746444 with three populations Chinese, Korean, Turkish were included in this study.

ResultsResults show that both allele frequency and genotype distributions of miR-146a rs2910164 polymorphism are significantly associated with susceptibility to HCC G versus C: OR = 1.153, 95% CI 1.083–1.228, P < 0.001; GC versus CC: OR = 1.165, 95% CI 1.054–1.286, P = 0.003; GG versus CC: OR = 1.361, 95% CI 1.192–1.553, P < 0.001; GG-GC versus CC: OR = 1.213, 95% CI 1.104–1.333, P < 0.001; GG versus GC-CC: OR = 1.210, 95% CI 1.080–1.356, P < 0.001. Our data suggest that people with G allele have a higher susceptibility to HCC as compared to those with C allele. However, meta-analysis failed to detect associations between miR-499 rs3746444 and HCC risk under each genetic model tested. Subgroup analysis showed that Chinese population with CC genotype are more vulnerable to HCC OR = 2.171, 95% CI = 1.149–4.104, P = 0.017 than those with TT genotype.

ConclusionsWe conclude that rs2910164 in miR-146a may confer susceptibility to HCC, especially in the Chinese population. No significant association was found between miR-499 rs3746444 and HCC, but subgroup study showed that subjects with CC genotype are more vulnerable to HCC than TT genotype in the Chinese population.

Electronic supplementary materialThe online version of this article doi:10.1186-s12881-014-0092-7 contains supplementary material, which is available to authorized users.

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Autor: Jiajing Liu - Bo Xie - Shuilian Chen - Feng Jiang - Wei Meng


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