Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate arteryReportar como inadecuado




Genetic network identifies novel pathways contributing to atherosclerosis susceptibility in the innominate artery - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Medical Genomics

, 7:51

Functional and structural genomics

Abstract

BackgroundAtherosclerosis, the underlying cause of cardiovascular disease, results from both genetic and environmental factors.

MethodsIn the current study we take a systems-based approach using weighted gene co-expression analysis to identify a candidate pathway of genes related to atherosclerosis. Bioinformatic analyses are performed to identify candidate genes and interactions and several novel genes are characterized using in-vitro studies.

ResultsWe identify 1 coexpression module associated with innominate artery atherosclerosis that is also enriched for inflammatory and macrophage gene signatures. Using a series of bioinformatics analysis, we further prioritize the genes in this pathway and identify Cd44 as a critical mediator of the atherosclerosis. We validate our predictions generated by the network analysis using Cd44 knockout mice.

ConclusionThese results indicate that alterations in Cd44 expression mediate inflammation through a complex transcriptional network involving a number of previously uncharacterized genes.

KeywordsAtherosclerosis Co-expression network inflammation Electronic supplementary materialThe online version of this article doi:10.1186-1755-8794-7-51 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Autor: Jody Albright - Pamela M Quizon - Aldons J Lusis - Brian J Bennett

Fuente: https://link.springer.com/







Documentos relacionados