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Molecular Neurobiology

, Volume 42, Issue 1, pp 4–9

First Online: 16 June 2010Received: 05 April 2010Accepted: 05 April 2010

Abstract

Apoptosis was a term introduced in 1972 to distinguish a mode of cell death with characteristic morphology and apparently regulated, endogenously driven mechanisms. The effector processes responsible for apoptosis are now mostly well known, involving activation of caspases and Bcl2 family members in response to a wide variety of physiological and injury-induced signals. The factors that lead of the decision to activate apoptosis as opposed to adaptive responses to such signals e.g. autophagy, cycle arrest, protein synthesis shutoff are less well understood, but the intranuclear Promyelocytic Leukaemia Body PML body may create a local microenvironment in which the audit of DNA damage may occur, informed by the extent of the damage, the adequacy of its repair and other aspects of cell status.

KeywordsCell death Apoptosis biology DNA  Download fulltext PDF



Autor: Andrew H. Wyllie

Fuente: https://link.springer.com/







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