Role of NADPH Oxidase in Metabolic Disease-Related Renal Injury: An UpdateReportar como inadecuado

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Oxidative Medicine and Cellular Longevity - Volume 2016 2016, Article ID 7813072, 8 pages -

Review ArticleDepartment of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China

Received 2 June 2016; Accepted 17 July 2016

Academic Editor: Juan F. Santibanez

Copyright © 2016 Cheng Wan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Metabolic syndrome has been linked to an increased risk of chronic kidney disease. The underlying pathogenesis of metabolic disease-related renal injury remains obscure. Accumulating evidence has shown that NADPH oxidase is a major source of intrarenal oxidative stress and is upregulated by metabolic factors leading to overproduction of ROS in podocytes, endothelial cells, and mesangial cells in glomeruli, which is closely associated with the initiation and progression of glomerular diseases. This review focuses on the role of NADPH oxidase-induced oxidative stress in the pathogenesis of metabolic disease-related renal injury. Understanding of the mechanism may help find potential therapeutic strategies.

Autor: Cheng Wan, Hua Su, and Chun Zhang



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