An Activity of Thioacyl Derivatives of 4-Aminoquinolinium Salts towards Biofilm Producing and Planktonic Forms of Coagulase-Negative StaphylococciReportar como inadecuado




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BioMed Research International - Volume 2015 2015, Article ID 725939, 10 pages -

Research Article

Department and Institute of Microbiology and Virology, School of Pharmacy and Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Jagiellońska 4, Sosnowiec, 41-200 Katowice, Poland

Department of Organic Chemistry, School of Pharmacy and Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Jagiellońska 4, Sosnowiec, 41-200 Katowice, Poland

Department of Conservative Dentistry with Endodontics, Medical University of Silesia, Plac Akademicki 17, Bytom, 41-902 Katowice, Poland

Received 18 July 2014; Revised 15 October 2014; Accepted 22 November 2014

Academic Editor: Madhab K. Chattopadhyay

Copyright © 2015 Robert D. Wojtyczka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Microorganisms present in different environments have developed specific mechanisms of settling on various abiotic and biotic surfaces by forming a biofilm. It seems to be well justified to search for new compounds enabling biofilm reduction, which is highly resistant to antibiotics. This study was thus an initial assessment of the antibacterial activity of two new quinoline derivatives of a structure of 3-thioacyl 1-methyl 4-arylaminoquinolinium salts against coagulase-negative staphylococci CoNS isolated from a hospital environment, in a form of both biofilms and in planktonic form. Thirty-three stains of CoNS isolated from the hospital environment air, surfaces and seven reference strains from the ATCC collection were selected for the study. The mean MIC value for 1-methyl-3-benzoylthio-4-4-chlorophenylaminoquinolinum chloride 4-chlorophenylamino derivative was 42.60 ± 19.91 μg-mL, and in the case of strains subjected to 1-methyl-3-benzoylthio-4-4-fluorophenylaminoquinolinum chloride 4-fluorophenylamino derivative activity, the mean MIC value was 43.20 ± 14.30 μg-mL. The mean concentration of 4-chlorophenylamino derivative that inhibited biofilm formation was 86.18 ± 30.64 μg-mL. The mean concentration of 4-fluorophenylamino derivatives that inhibited biofilm formation was higher and amounted to 237.09 ± 160.57 μg-mL. Based on the results, both derivatives of the examined compounds exhibit high antimicrobial activity towards strains growing both in planktonic and biofilm form.





Autor: Robert D. Wojtyczka, Andrzej Zięba, Arkadiusz Dziedzic, Małgorzata Kępa, and Danuta Idzik

Fuente: https://www.hindawi.com/



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