Anti-Inflammatory, Immunomodulatory, and Heme Oxygenase-1 Inhibitory Activities of Ravan Napas, a Formulation of Uighur Traditional Medicine, in a Rat Model of Allergic AsthmaReportar como inadecuado




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Evidence-Based Complementary and Alternative MedicineVolume 2011 2011, Article ID 725926, 13 pages

Research Article

First Affiliated Hospital, Xinjiang Medical University, Xinjiang 830011, China

Department of Traditional Uighur Medicine, Xinjiang Medical University, Xinjiang 830011, China

Department of Pharmacology, Université de Bordeaux, 33076 Bordeaux, France

Received 9 May 2010; Revised 1 July 2010; Accepted 13 August 2010

Copyright © 2011 Sajida Abdureyim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ravan Napas RN is a traditional formula used to treat pulmonary symptoms and diseases such as coughing, breathing difficulty, and asthma in traditional Uighur medicine. The purpose of this study was to investigate the anti-inflammatory, and immuno-modulatory activity of RN in a well-characterized animal model of allergic asthma. Rats were sensitized with intraperitoneal ip ovalbumin OVA and alum, and then challenged with OVA aerosols. The asthma model rats were treated with RN; saline- and dexamethasone- DXM- treated rats served as normal and model controls. The bronchoalveolar lavage fluid BALF cellular differential and the concentrations of sICAM-1, IL-4, IL-5, TNF- , INF- , and IgE in serum were measured. Lung sections underwent histological analysis. The immunohistochemistry S-P method was used to measure the expression of ICAM-1 and HO-1 in the lung. RN significantly reduced the number of inflammatory cells in BALF and lung tissues, decreased sICAM-1, IL-4, IL-5, TNF- , and IgE in serum, and increased serum INF- . There was a marked suppression of ICAM-1 and HO-1 expression in the lung. Our results suggest that RN may have an anti-inflammatory and immuneregulatory effect on allergic bronchial asthma by modulating the balance between Th1-Th2 cytokines.





Autor: Sajida Abdureyim, Nurmuhammat Amat, Anwar Umar, Halmurat Upur, Benedicte Berke, and Nicholas Moore

Fuente: https://www.hindawi.com/



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