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Advances in Artificial Neural SystemsVolume 2009 2009, Article ID 724092, 10 pages

Research ArticleGraduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu-ku, Kitakyushu-shi, Fukuoka 808-0196, Japan

Received 1 April 2008; Revised 28 June 2008; Accepted 4 October 2008

Academic Editor: Akira Imada

Copyright © 2009 Masaaki Takahashi and Kiyohisa Natsume. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In order to simulate neuronal electrical activities, we must estimate the dynamics of channel conductances from physiological experimental data. However, this approach requires the formulation of differential equations that express the time course of channel conductance. On the other hand, if the dynamics are automatically estimated, neuronal activities can be easily simulated. By using a recurrent neural network RNN, it is possible to estimate the dynamics of channel conductances without formulating the differential equations. In the present study, we estimated the dynamics of the and conductances of a squid giant axon using two different fully connected RNNs and were able to reproduce various neuronal activities of the axon. The reproduced activities were an action potential, a threshold, a refractory phenomenon, a rebound action potential, and periodic action potentials with a constant stimulation. RNNs can be trained using channels other than the and channels. Therefore, using our RNN estimation method, the dynamics of channel conductance can be automatically estimated and the neuronal activities can be simulated using the channel RNNs. An RNN can be a useful tool to estimate the dynamics of the channel conductance of a neuron, and by using the method presented here, it is possible to simulate neuronal activities more easily than by using the previous methods.

Autor: Masaaki Takahashi and Kiyohisa Natsume



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