Lactoferrin Promotes Early Neurodevelopment and Cognition in Postnatal Piglets by Upregulating the BDNF Signaling Pathway and PolysialylationReportar como inadecuado




Lactoferrin Promotes Early Neurodevelopment and Cognition in Postnatal Piglets by Upregulating the BDNF Signaling Pathway and Polysialylation - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Molecular Neurobiology

, Volume 52, Issue 1, pp 256–269

First Online: 23 August 2014Received: 12 June 2014Accepted: 06 August 2014

Abstract

Lactoferrin Lf is a sialic acid Sia-rich, iron-binding milk glycoprotein that has multifunctional health benefits. Its potential role in neurodevelopment and cognition remains unknown. To test the hypothesis that Lf may function to improve neurodevelopment and cognition, the diet of postnatal piglets was supplemented with Lf from days 3 to 38. Expression levels of selected genes and their cognate protein profiles were quantitatively determined. The importance of our new findings is that Lf 1 upregulated several canonical signaling pathways associated with neurodevelopment and cognition; 2 influenced ~10 genes involved in the brain-derived neurotrophin factor BDNF signaling pathway in the hippocampus and upregulated the expression of polysialic acid, a marker of neuroplasticity, cell migration and differentiation of progenitor cells, and the growth and targeting of axons; 3 upregulated transcriptional and translational levels of BDNF and increased phosphorylation of the cyclic adenosine monophosphate cAMP response element-binding protein, CREB, a downstream target of the BDNF signaling pathway, and a protein of crucial importance in neurodevelopment and cognition; and 4 enhanced the cognitive function and learning of piglets when tested in an eight-arm radial maze. The finding that Lf can improve neural development and cognition in postnatal piglets has not been previously described.

KeywordsLactoferrin BDNF signaling pathway CREB Polysialic acid-NCAMs Neurodevelopment Gene microarray and qPCR Cognition Electronic supplementary materialThe online version of this article doi:10.1007-s12035-014-8856-9 contains supplementary material, which is available to authorized users.

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Autor: Yue Chen - Zhiqiang Zheng - Xi Zhu - Yujie Shi - Dandan Tian - Fengjuan Zhao - Ni Liu - Petra S. Hüppi - Frederic A. T

Fuente: https://link.springer.com/







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