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* Corresponding author 1 IGH - Institut de génétique humaine 2 Department of Pathology 3 CRBM - Centre de recherches de biochimie macromoléculaire

Abstract : The bone morphogenetic protein BMP signaling pathway plays an essential role during gastrointestinal GI tract development in vertebrates. In the present study, we use an antibody that recognizes the phosphorylated and activated form of Smad1, 5, and 8 to examine by immunohistochemistry the endogenous patterns of BMP signaling pathway activation in the developing GI tract. We show that the endogenous BMP signaling pathway is activated in the mesoderm, the endoderm, and the enteric nervous system ENS of the developing chick GI tract and is more widespread than BMP ligand expression patterns. Using an avian-specific retroviral misexpression technique to activate or inhibit BMP signaling pathway activity in the mesoderm of the gut, we show that BMP activity is required for the pattern, the development, and the differentiation of all three tissue types of the gut: mesoderm that forms the visceral smooth muscle, endoderm that forms the epithelium, and ectoderm that forms the ENS. These results demonstrate that BMP signaling is activated in all the tissue layers of the GI tract during the development and plays a role during interactions and reciprocal communications of these tissue layers.

Keywords : BMP Visceral Smooth Muscle Stomach Chick





Autor: Pascal De Santa Barbara - Jerrell Williams - Allan Goldstein - Adele Doyle - Corinne Nielsen - Sarah Winfield - Sandrine Faure -

Fuente: https://hal.archives-ouvertes.fr/



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