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Mediators of InflammationVolume 2009 2009, Article ID 689430, 8 pages

Research Article

UMR CNRS 6101, Centre National de la Recherche Scientifique, Faculté de Médecine, Université de Limoges, 2 rue Dr. Marcland, 87025 Limoges, France

Service d'Anatomie Pathologique, CHU Dupuytren, 87045 Limoges, France

Service de Neurochirurgie, CHU Dupuytren, 87045 Limoges, France

Received 7 September 2009; Revised 25 November 2009; Accepted 21 December 2009

Academic Editor: Muzamil  Ahmad

Copyright © 2009 Yves Denizot et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In view of the important oncogenic action of phospholipase we investigated transcripts in human meningiomas. Real-time PCR was used to investigate transcripts in 26 human meningioma tumors. Results indicated that three -dependent high molecular weight -IVA, -IVB, -IVC, one -independent high molecular weight -VI and five low molecular weight secreted forms of -IB, -IIA, -III, -V, and -XII are expressed with -IVA, -IVB, -VI, and -XIIA as the major expressed forms. -IIE, -IIF, -IVD, and -XIIB are not detected. Plasma -VIIA and intracellular -VIIB platelet-activating factor acetylhydrolase transcripts are expressed in human meningiomas. However no difference was found for transcript amounts in relation to the tumor grade, the subtype of meningiomas, the presence of inflammatory infiltrated cells, of an associated edema, mitosis, brain invasion, vascularisation or necrosis. In conclusion numerous genes encoding multiples forms of are expressed in meningiomas where they might act on the phospholipid remodeling and on the local eicosanoid and-or cytokine networks.

Autor: Yves Denizot, Rafael De Armas, Karine Durand, Sandrine Robert, Jean-Jacques Moreau, François Caire, Nicolas Weinbreck, and



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