Extrastriate projections in human optic radiation revealed by fMRI-informed tractographyReportar como inadecuado

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Brain Structure and Function

, Volume 220, Issue 5, pp 2519–2532

First Online: 06 June 2014Received: 20 December 2013Accepted: 14 May 2014


The human optic radiation OR is the main pathway for conveying visual input to occipital cortex, but it is unclear whether it projects beyond primary visual cortex V1. In this study, we used functional MRI mapping to delineate early visual areas in 30 healthy volunteers and determined the termination area of the OR as reconstructed with diffusion tractography. Direct thalamo-cortical projections to areas V2 and V3 were found in all hemispheres tested, with a distinct anatomical arrangement of superior–inferior fiber placement for dorsal and ventral projections, respectively, and a medio-lateral nesting arrangement for projections to V1, V2 and V3. Finally, segment-specific microstructure was examined, revealing sub-fascicular information. This is to date the first in vivo demonstration of direct extrastriate projections of the OR in humans.

KeywordsOptic radiation Visual pathways Extrastriate fMRI Diffusion tensor imaging Tractography  Download fulltext PDF

Autor: Ivan Alvarez - D. Samuel Schwarzkopf - Chris A. Clark

Fuente: https://link.springer.com/

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