Statins Do Not Influence Long-Term Rituximab Clinical Efficiency in Rheumatoid Arthritis PatientsReportar como inadecuado

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BioMed Research International - Volume 2014 2014, Article ID 689426, 4 pages -

Clinical Study

Department of Rheumatology, “Sfanta Maria” Hospital, Blvd IonMihalache No. 37-39, 011172 Bucharest, Romania

“Carol Davila” University of Medicine, Bucharest, Romania

Received 30 April 2013; Accepted 21 October 2013; Published 8 January 2014

Academic Editor: Shigeru Kotake

Copyright © 2014 Diana Mazilu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. This longitudinal study aims to determine if statins inhibit the response to rituximab in rheumatoid arthritis RA patients. Methods. 41 patients initiating rituximab were included; 17 patients were exposed to the combination of statins and rituximab. The total cholesterol, erythrocyte sedimentation rate ESR, and C-reactive protein CRP were assessed. The clinical response was evaluated using Disease Activity Score DAS28 and European League against Rheumatism EULAR response at 6 and 18 months. Results. A tendency of increasing in DAS28 was observed in statin-exposed group but the correlation was very weak at 18 months: , . The statin-exposed status was negatively and very weakly correlated with EULAR response at 6 months , and 18 months , . There was a negative correlation between statin-exposed status and inflammatory markers values ESR and CRP; however, the correlation was very weak. The use of statin did not influence the cardiovascular risk measured by modified Systematic Coronary Risk Evaluation mSCORE. Conclusions. Long-term significant inhibitory effects of statins on rituximab treatment in RA have not been proved using clinical response scores or biologic markers.

Autor: Diana Mazilu, Tania Gudu, Ruxandra Ionescu, and Daniela Opris



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