Association between Thrombophilia and the Post-Thrombotic SyndromeReport as inadecuate

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International Journal of Vascular MedicineVolume 2013 2013, Article ID 643036, 7 pages

Review Article Center for Clinical Epidemiology, Jewish General Hospital, 3755 Côte Saint Catherine Room H420.1, Montreal, QC, Canada H3T 1E2

Received 22 February 2013; Revised 4 April 2013; Accepted 17 April 2013

Academic Editor: Raghid Kreidy

Copyright © 2013 Anat Rabinovich and Susan R. Kahn. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The post thrombotic syndrome PTS is a chronic condition that develops in 20%–40% of deep vein thrombosis DVT patients. While risk factors that predispose to the development of venous thromboembolism VTE are widely known, factors that influence the development of PTS after DVT have not been well elucidated. Over 10% of the general population is affected by one or more identifiable inherited thrombophilias which have been shown to underlie at least 1-3 of cases of VTE. The various thrombophilias are important risk factors for VTE, but it is unknown whether they also increase the risk for development of PTS. We performed a review of studies that have reported on the association between thrombophilia and the development of PTS in populations of patients with DVT and with chronic venous ulcers. Studies vary with regards to the definition of PTS, study design, follow-up period, and present conflicting results. Based on these results, the question of whether thrombophilia predisposes to the development of PTS remains unanswered.

Author: Anat Rabinovich and Susan R. Kahn



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