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Tumor Biology

, Volume 35, Issue 11, pp 11409–11414

First Online: 15 August 2014Received: 11 July 2014Accepted: 06 August 2014

Abstract

T cell immunoglobulin domain and mucin domain-containing molecule 3 Tim-3 is a newly discovered immunomodulatory, which plays an important role in immunity regulation. Recent evidence suggests that Tim-3 is differentially regulated in a variety of tumors and has a potential as a therapeutic target. The aim of this study was to investigate the effect of Tim-3 on the development of prostate cancer PCa. Tim-3 expressing on peripheral CD4+ T and CD8+ T cells was analyzed by flow cytometry. The relationships between Tim-3 expression and clinicopathological features were analyzed. Immunohistochemical expression of Tim-3 was examined in our large numbers of paraffin-fixed prostate tissues. Flow cytometry revealed that expression of Tim-3 was significantly increased on both CD4+ and CD8+ T cells in PCa patients than that in benign prostate hyperplasia BPH patients. Also, the level of Tim-3 on CD4+ T cells was positively correlated with CD8+ T cells in patients. Further analyses revealed that the levels of Tim-3 on CD4+ T cells and CD8+ T cells exhibited different expression patterns in terms of localization depending on pathological category of PCa and metastasis. Immunohistochemical analysis revealed that positive staining of Tim-3 in PCa but little or no staining of Tim-3 was observed in BPH epithelium. Tim-3 may affect the development and progression of PCa, which may provide knowledge for using Tim-3 as a novel therapy for effective PCa management.

KeywordsProstate cancer Tim-3 CD4+ T cells CD8+ T cells The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics COPE. After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article can be found online at http:-dx.doi.org-10.1007-s13277-017-5487-6.

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Autor: Yong-Rui Piao - Zhe-Hu Jin - Kui-Chang Yuan - Xuan-Shun Jin

Fuente: https://link.springer.com/article/10.1007/s13277-014-2464-1



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