CD49b, a Major Marker of Regulatory T-Cells Type 1, Predicts the Response to Antiviral Therapy of Recurrent Hepatitis C after Liver TransplantationReportar como inadecuado




CD49b, a Major Marker of Regulatory T-Cells Type 1, Predicts the Response to Antiviral Therapy of Recurrent Hepatitis C after Liver Transplantation - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

1 CR Saint-Antoine - Centre de Recherche Saint-Antoine 2 Centre de transplantation hépatique 3 IBLI - Institut de biologie de Lille - IBL 4 Unité de biostatistique

Abstract : The TRANSPEG study was a prospective study to assess the efficacy of antiviral therapy in patients with a recurrent hepatitis C virus HCV after liver transplantation. The influence of regulatory T-cells Tregs on the response to antiviral therapy was analyzed. Patients were considered as a function of their sustained virological response SVR at 18 months after treatment initiation. A transcriptomic analysis was performed to assess Treg markers Tr1 and FoxP3 + in serum, PBMC, and liver biopsies. 100 patients had been included in the TRANSPEG study. Data from 27 of these patients were available. The results showed that the expression of CD49b a predominant marker of Tr1 before the introduction of antiviral therapy was significantly associated with SVR. Responders displayed lower serum levels of CD49b than nonresponders P < 0.02. These findings were confirmed in PBMC and liver biopsies even if in a nonsignificant manner for the limited number of samples. The assessment of CD49b levels is thus predictive of the response to antiviral therapy. This data suggests that CD49b may be a marker of the failure of the immune response and antiviral therapy during HCV recurrence. The assessment of CD49b could help to select patients who require earlier and more intensive antiviral therapy.





Autor: Fabien Stenard - Olivier Morales - Khaldoun Ghazal - Vivian Viallon - Lynda Aoudjehane - Laurissa Ouaguia - Gautier Goormachtigh

Fuente: https://hal.archives-ouvertes.fr/



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