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1 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute

Abstract : The analysis of multi-unit extracellular recordings of brain activity has led to the development of numerous tools, ranging from signal processing algorithms to electronic devices and applications. Currently, the evaluation and optimisation of these tools are hampered by the lack of ground-truth databases of neural signals. These databases must be parameterisable, easy to generate and bio-inspired, i.e. containing features encountered in real electrophysiological recording sessions. Towards that end, this article introduces an original computational approach to create fully annotated and parameterised benchmark datasets, generated from the summation of three components: neural signals from compartmental models and recorded extracellular spikes, non-stationary slow oscillations, and a variety of different types of artefacts. We present three application examples. 1 We reproduced in-vivo extracellular hippocampal multi-unit recordings from either tetrode or polytrode designs. 2 We simulated recordings in two different experimental conditions: anaesthetised and awake subjects. 3 Last, we also conducted a series of simulations to study the impact of different level of artefacts on extracellular recordings and their influence in the frequency domain. Beyond the results presented here, such a benchmark dataset generator has many applications such as calibration, evaluation and development of both hardware and software architectures.





Autor: Sirenia Lizbeth Mondragón-González - Eric Burguière -

Fuente: https://hal.archives-ouvertes.fr/



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