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1 MIVEGEC - Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle 2 IRSS - Institut de Recherche en Sciences de la Santé 3 Institut de Recherche en Sciences de la Santé IRSS - Centre Muraz 4 UMMISCO - Unité de modélisation mathématique et informatique des systèmes complexes Bondy

Abstract : Exposure to stress during an insect’s larval development can have carry-over effects on adult life history traits and susceptibility to pathogens. We investigated the effects of larval nutritional stress for the first time using field mosquito vectors and malaria parasites. In contrast to previous studies, we show that larval nutritional stress may affect human to mosquito transmission antagonistically: nutritionally deprived larvae showed lower parasite prevalence for only one gametocyte carrier; they also had lower fecundity. However, they had greater survival rates that were even higher when infected. When combining these opposing effects into epidemiological models, we show that larval nutritional stress induced a decrease in malaria transmission at low mosquito densities and an increase in transmission at high mosquito densities, whereas transmission by mosquitoes from well-fed larvae was stable. Our work underscores the importance of including environmental stressors towards understanding host–parasite dynamics to improve disease transmission models and control.





Autor: Amélie Vantaux - Thierry Lefèvre - Anna Cohuet - Kounbobr Roch Dabiré - Benjamin Roche - Olivier Roux -

Fuente: https://hal.archives-ouvertes.fr/



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