Ultrapure laser-synthesized Si-based nanomaterials for biomedical applications: in vivo assessment of safety and biodistributionReportar como inadecuado




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1 CRO2 - Centre de Recherches en Oncologie biologique et Oncopharmacologie 2 LP3 - Laboratoire Lasers, Plasmas et Procédés photoniques 3 TIMONE - Hôpital de la Timone CHU - APHM 4 Institut National de Recherches et d-Analyses Physicochimiques Tunisie 5 AMU MED - Aix-Marseille Université - Faculté de médecine

Abstract : Si-SiO x nanoparticles NPs produced by laser ablation in deionized water or aqueous biocompatible solutions present a novel extremely promising object for biomedical applications, but the interaction of these NPs with biological systems has not yet been systematically examined. Here, we present the first comprehensive study of biodistribution, biodegradability and toxicity of laser-synthesized Si-SiO x nanoparticles using a small animal model. Despite a relatively high dose of Si-NPs 20 mg-kg administered intravenously in mice, all controlled parameters serum, enzymatic, histological etc. were found to be within safe limits 3 h, 24 h, 48 h and 7 days after the administration. We also determined that the nanoparticles are rapidly sequestered by the liver and spleen, then further biodegraded and directly eliminated in urine without any toxicity effects. Finally, we found that intracellular accumulation of Si-NPs does not induce any oxidative stress damage. Our results evidence a huge potential in using these safe and biodegradable NPs in biomedical applications, in particular as vectors, contrast agents and sensitizers in cancer therapy and diagnostics theranostics.





Autor: Tarek Baati - Ahmed Al-Kattan - Marie-Anne Esteve - Leila Njim - Yury Ryabchikov - Florence Chaspoul - Mohamed Hammami - Marc Sen

Fuente: https://hal.archives-ouvertes.fr/



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