Preoperative Thyrotropin Serum Concentrations Gradually Increase from Benign Thyroid Nodules to Papillary Thyroid Microcarcinomas Then to Papillary Thyroid Cancers of Larger SizeReportar como inadecuado




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Journal of Thyroid ResearchVolume 2012 2012, Article ID 530721, 4 pages

Research Article

Department of Endocrinology, Hospital General Universitari Vall d-Hebron, Pg. Vall d-Hebron 119-129, 08035 Barcelona, Spain

Department of Surgery, Unit of Endocrinological Surgery, Hospital General Universitari Vall d-Hebron, 08035 Barcelona, Spain

Department of Pathology, Hospital General Universitari Vall d-Hebron, 08035 Barcelona, Spain

Received 3 March 2011; Revised 26 May 2011; Accepted 14 June 2011

Academic Editor: Nikola Bešič

Copyright © 2012 Carles Zafon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We evaluated the preoperative serum thyrotropin TSH levels in 386 patients operated on for nodular thyroid disease NTD. TSH levels for cases with final benign disease and differentiated thyroid carcinoma DTC were compared. No evidence of cancer was detected in 310 patients 80.3%, whereas malignancy was present in 76 cases 19.7%. Mean TSH concentration was 1 . 3 6 ± 1 . 6 2  mU-L in benign patients and 2 . 0 8 ± 2 . 1 in cases with malignant lesions 𝑃 = 0 . 0 0 1 3 . The group of malignancy was subdivided in papillary thyroid carcinoma PTMC versus thyroid cancer of larger size TCLS. Mean TSH was 1 . 7 1 ± 1 . 5 2 in PTMC and 2 . 4 2 ± 2 . 5 in TCLS. Significant differences were found when all groups benign, PTMC and TCLS were compared 𝑃 < 0 . 0 0 1 . However, pairwise comparisons between them showed that differences were only significant between benign and TCLS groups 𝑃 < 0 . 0 1 . In conclusion, TSH levels were higher in patients with a final diagnosis of DTC. Moreover, it appears that there exists an increment in tumor size as a function of increment in the TSH level.





Autor: Carles Zafon, Gabriel Obiols, Juan Antonio Baena, Josep Castellví, Belen Dalama, and Jordi Mesa

Fuente: https://www.hindawi.com/



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