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International Journal of NephrologyVolume 2013 2013, Article ID 530713, 1 page


Nephrology Division, Department of Internal Medicine, Seoul National University Hospital, 101 Daehakro, Chongno Gu, Seoul 110-744, Republic of Korea

Nephrology Division, Kyungpook National University Hospital, Daegu, Republic of Korea

Division of Nephrology, University of Hong Kong, Hong Kong

Department of Medicine, McMaster University, Hamilton, ON, Canada

Received 23 September 2013; Accepted 23 September 2013

Copyright © 2013 Kook-Hwan Oh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Peritoneal dialysis PD has been widely used as one of the major renal replacement therapies RRT for end-stage renal disease ESRD patients. Although PD therapy has witnessed remarkable technical advances, and the patient’s survival early after starting PD is comparable, or superior, to that of hemodialysis, it is currently faced with many challenges. Long-term PD is associated with progressive loss of UF capacity, resulting in increased cardiovascular morbidity or ultimate discontinuation of PD. This is related to inflammation, new vessel formation angiogenesis, and fibrotic thickening of the peritoneal membrane PM. Bioincompatible PD fluid, along with peritonitis, is the major contributor to the PM change. In order to establish PD as a more general and longstanding renal replacement therapy, clinicians and scientists need to investigate the pivotal issues such as adequate volume control and long-term preservation of the peritoneal membrane and the prevention from devastating conditions such as encapsulating peritoneal sclerosis.

In this special issue, we have compiled elegant reviews and clinical studies with a special interest in the above-mentioned “Contemporary issues of PD therapy.” This special issue deals with many of the current issues such as PD catheter implantation by nephrologists, clinical benefits of the newer biocompatible PD fluid, peritonitis, and how to cope with low ultrafiltration volume with bimodal and twice-daily icodextrin use and several others. It is the hope of our editorial committee that this special issue will contribute to an improved patient care and serve as a stimulus to seek a new knowledge in renal replacement therapy.

Kook-Hwan OhYong-Lim KimWai-Kei LoPeter J. Margetts

Autor: Kook-Hwan Oh, Yong-Lim Kim, Wai-Kei Lo, and Peter J. Margetts



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