Lobar hepatocellular carcinoma with ipsilateral portal vein tumor thrombosis treated with yttrium-90 glass microsphere radioembolization: preliminary results.Reportar como inadecuado




Lobar hepatocellular carcinoma with ipsilateral portal vein tumor thrombosis treated with yttrium-90 glass microsphere radioembolization: preliminary results. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

* Corresponding author 1 Foie, métabolismes et cancer 2 CRLCC - CRLCC Eugène Marquis 3 Microenvironnement et remodelage Foie, métabolismes et cancer 4 Institut Paoli Calmettes 5 Microenvironnement et remodelage Foie, métabolismes et cancer, CRLCC - CRLCC Eugène Marquis

Abstract : Portal vein tumor thrombosis PVTT is a common complication of hepatocellular carcinoma HCC and has a negative impact on prognosis. This characteristic feature led to the rationale of the present trial designed to assess the efficacy and the safety of yttrium-90 glass-microsphere treatment for advanced-stage lobar HCC with ipsilateral PVTT. 18 patients with unresectable lobar HCC and ipsilateral PVTT were treated in our institution with 90Y-microS radioembolization. Patients were evaluated every 3 to 6 months for response, survival, and toxicity. Mean follow-up was 13.0 months 2.2-50.6. Outcomes were: complete response n = 2, partial response n = 13, stable disease n = 1, and progressive disease n = 2 giving a disease control rate of 88.9%. Four patients were downstaged. Treating lobar hepatocellular carcinoma with ipsilateral portal vein thrombosis with yttrium-90 glass-microsphere radioembolization is safe and efficacious. Further clinical trials are warranted to confirm these results and to compare 90Y-microS with sorafenib, taking into account not only survival but also the possibility of secondary surgery for putative curative intention after downstaging.





Autor: Marc Pracht - Julien Edeline - Laurence Lenoir - M. Latournerie - Habiba Mesbah - Yan Rolland - Odile Audrain - Bruno Clément -

Fuente: https://hal.archives-ouvertes.fr/



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