Long non-coding RNA TUSC7 acts a molecular sponge for miR-10a and suppresses EMT in hepatocellular carcinomaReportar como inadecuado




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Tumor Biology

, Volume 37, Issue 8, pp 11429–11441

First Online: 22 March 2016Received: 18 November 2015Accepted: 19 January 2016

Abstract

Despite advances in the roles of long non-coding RNA lncRNA tumor suppressor candidate 7 TUSC7 in cancer biology, which has been identified as a tumor suppressor by regulating cell proliferation, apoptosis, migration, invasion, cell cycle, and tumor growth, the function of TUSC7 in hepatocellular carcinoma HCC remains unknown.
In this study, we observed that the expression of TUSC7 was immensely decreased in HCC.
Clinically, the lower expression of TUSC7 predicted poorer survival and may be an independent risk factor for HCC patients.
Moreover, TUSC7 inhibited cell metastasis, invasion, and epithelial-to-mesenchymal transformation EMT through competitively binding miR-10a.
Furthermore, we found that TUSC7 could decrease the expression of Eph tyrosine kinase receptor A4 EphA4, a downstream target of miR-10a as well as an EMT suppressor, through TUSC7-miR-10a-EphA4 axis.
Taken together, we demonstrate that TUSC7 suppresses EMT through the TUSC7-miR-10a-EphA4 axis, which may be a potential target for therapeutic intervention in HCC.

KeywordsTUSC7 miR-10a EphA4 EMT HCC Yufeng Wang and Zhikui Liu contributed equally to this work.

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Autor: Yufeng Wang - Zhikui Liu - Bowen Yao - Changwei Dou - Meng Xu - Yumo Xue - Linglong Ding - Yuli Jia - Hongyong Zhang - Qi

Fuente: https://link.springer.com/article/10.1007/s13277-016-4892-6



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