Prognostic value of three different lymph node staging systems in the survival of patients with gastric cancer following D2 lymphadenectomyReportar como inadecuado




Prognostic value of three different lymph node staging systems in the survival of patients with gastric cancer following D2 lymphadenectomy - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Tumor Biology

, Volume 37, Issue 8, pp 11105–11113

First Online: 24 February 2016Received: 17 August 2015Accepted: 01 October 2015

Abstract

The log odds of positive lymph nodes LODDS was defined as the log of the ratio between the number of positive lymph nodes and the number of negative lymph nodes, which is a novel and promising nodal staging system for gastric cancer.
Here, we aimed to compare the prognostic effect of pN, lymph node ratio LNR and LODDS.
The association between overall survival and pN, LNR and LODDS was retrospectively analysed.
The discriminatory ability and monotonicity of gradients linear trend χ score, homogeneity ability likelihood ratio test and prognostic stratification ability Akaike information criterion AIC and receiver operating characteristic ROC curve were compared among three lymph node staging systems.
The pN, LNR and LODDS were all identified as independent prognostic factors for gastric cancer patients in the multivariate analysis.
LODDS showed the best prognostic performance linear trend χ score 266.743, likelihood ratio χ test score 427.771, AIC value 5670.226, area under the curve AUC 0.793, followed by LNR and pN.
In patients with different levels of retrieved lymph nodes ≤10, 11–14, 15–25 and >25, LODDS was the most powerful for prognostic prediction and discrimination of the heterogeneity among the subgroups.
Significant differences in survival were observed among patients in different LODDS subgroups after being classified according to the pN and LNR classifications.
LODDS appears to be a more powerful system for predicting the overall survival of gastric cancer patients, as compared to LNR and pN, and may serve as an alternative nodal staging system for gastric cancer.

KeywordsLog odds of positive lymph nodes Lymph node ratio Nodal system Prognosis Gastric cancer Chen Jian-hui and Cai Shi-rong contributed equally to this work.

Download fulltext PDF



Autor: Chen Jian-hui - Cai Shi-rong - Wu Hui - Chen Si-le - Xu Jian-bo - Zhai Er-tao - Chen Chuang-qi - He Yu-long

Fuente: https://link.springer.com/article/10.1007/s13277-015-4191-7



DESCARGAR PDF




Documentos relacionados