Pre-diagnostic serum levels of EGFR and ErbB2 and genetic glioma risk variants: a nested case-control studyReportar como inadecuado




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Tumor Biology

, Volume 37, Issue 8, pp 11065–11072

First Online: 23 February 2016Received: 04 November 2015Accepted: 27 December 2015

Abstract

Genetic variants have been associated with the risk of developing glioma, but functional mechanisms on disease phenotypic traits remain to be investigated.
One phenotypic trait of glioblastoma is the mutation and amplification of the epidermal growth factor receptor EGFR gene.
We investigated associations between pre-diagnostic serum protein concentrations of EGFR and ErbB2, both members of the EGFR family, and future risk of glioma.
Further, we studied if EGFR glioma risk variants were associated with EGFR and ErbB2 serum levels.
We assessed the associations between genetic glioma risk variants and serum concentrations of EGFR and ErbB2, as measured in pre-diagnostic cohort serum samples of 593 glioma patients and 590 matched cancer-free controls.
High serum EGFR and ErbB2 levels were associated with risk of developing glioblastoma P = 0.008; OR = 1.58, 95 % CI = 1.13–2.22 and P = 0.017, OR = 1.63, 95 % CI = 1.09–2.44, respectively.
High serum ErbB2 concentration was also associated with glioma risk overall P = 0.049; OR = 1.39, 95 % CI = 1.00–1.93.
Glioma risk variants were not associated with high serum protein abundance.
In contrast, the EGFR risk variant rs4947986 T was correlated with decreased EGFR serum levels study cohort P = 0.024 and controls P = 0.009.
To our knowledge, this is the first study showing an association of EGFR and ErbB2 serum levels with glioma more than a decade before diagnosis, indicating that EGFR and ErbB2 serum proteins are important in early gliomagenesis.
However, we did not find evidence that glioma risk variants were associated with high pre-diagnostic serum concentrations of EGFR and ErbB2.

KeywordsGlioma SNP Serum EGFR Serum ErbB2 Pre‐diagnostic Electronic supplementary materialThe online version of this article doi:10.1007-s13277-015-4742-y contains supplementary material, which is available to authorized users.

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Autor: Florentin Späth - Ulrika Andersson - Anna M. Dahlin - Hilde Langseth - Eivind Hovig - Tom Børge Johannesen - Kjell Gran

Fuente: https://link.springer.com/article/10.1007/s13277-015-4742-y



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