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Journal of Oncology - Volume 2014 2014, Article ID 371570, 5 pages -

Research Article

Oral Oncology Center, Department of Pathology and Clinical Propedeutics, Araçatuba School of Dentistry, Universidade Estadual Paulista UNESP, Brazil

Araçatuba Pathology Institute, Brazil

Oral Oncology Center, Department of Pathology and Clinical Propedeutics, 1193 José Bonifácio Street, 16015-050 Araçatuba, SP, Brazil

Received 26 June 2014; Revised 6 September 2014; Accepted 9 September 2014; Published 30 September 2014

Academic Editor: Michiel W. M. van den Brekel

Copyright © 2014 Gláucia Resende Soares et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of this study was to evaluate the survival of patients with SCC of the oropharynx, according to the presence of HPV and tobacco consumption. A total of 37 patients were followed up for at least 5 years after being diagnosed with SCC of the oropharynx. The biopsy tissue was submitted to the polymerase chain reaction PCR and in situ hybridization ISH methods for broad determination of HPV presence, to identify the presence of high-risk viruses 16 and 18. 12 of the 37 32.4% samples were HPV positive, whereas the two specific types of virus were identified in two samples for HPV-16 and in no samples for HPV-18. We observed no significant effect of the virus in survival analysis, irrespective of tobacco consumption. The level of tobacco consumption was significantly higher in the group of HPV-negative patients , in which all the patients in this group were smokers. Therefore, HPV did not change the survival of patients with SCC of the oropharynx in this study, indicating that factors other than tobacco need to be studied in conjunction with it, and the level of tobacco consumption is significantly higher in the group of HPV-negative patients.





Autor: Gláucia Resende Soares, Adriana Demathé, Neivio José Mattar, Éder Ricardo Biasoli, and Glauco Issamu Miyahara

Fuente: https://www.hindawi.com/



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