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BMC Psychiatry

, 10:64

First Online: 22 August 2010Received: 15 December 2009Accepted: 22 August 2010

Abstract

BackgroundPoor adherence to antidepressant therapy is an important barrier to the effective management of major depressive disorder. This study aims to quantify the adherence rate to antidepressant treatment and to determine the pattern of prescriptions of depressed patients in a psychiatric institute in Thailand.

MethodsThis retrospective study used electronic pharmacy data of outpatients aged 15 or older, with a new diagnosis of major depression who received at least one prescription of antidepressants between August 2005 and September 2008. The medication possession ratio MPR was used to measure adherence over a 6 month period.

Results1,058 were eligible for study inclusion. The overall adherence MPR > 80% in those attending this facility at least twice was 41% but if we assume that all patients who attended only once were non-adherent, adherence may be as low as 23%. Fluoxetine was the most commonly prescribed drug followed by TCAs. A large proportion of cases received more than one drug during one visit or was switched from one drug to another 39%.

ConclusionsAdherence to antidepressant therapy for treatment of major depression in Thailand is rather low compared to results of adherence from elsewhere.

AbbreviationsCMAContinuous, multiple-interval medications availability

MPRMedication possession ratio

SEStandard error

LOTLength of therapy

DALYsDisability Adjusted Life Years

SSRIsSelective serotonin reuptake inhibitors

TCAsTricyclic antidepressants

TRDTreatment-resistant depression

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Autor: Benjamas Prukkanone - Theo Vos - Philip Burgess - Nathorn Chaiyakunapruk - Melanie Bertram

Fuente: https://link.springer.com/



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