Acetylcholinesterase Inhibitors AChEIs for the treatment of visual hallucinations in schizophrenia: A review of the literatureReportar como inadecuado




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BMC Psychiatry

, 10:69

First Online: 07 September 2010Received: 20 February 2010Accepted: 07 September 2010

Abstract

BackgroundVisual hallucinations occur in various neurological diseases, but are most prominent in Lewy body dementia, Parkinson-s disease and schizophrenia. The lifetime prevalence of visual hallucinations in patients with schizophrenia is much more common than conventionally thought and ranges from 24% to 72%. Cortical acetylcholine ACh depletion has been associated with visual hallucinations; the level of depletion being related directly to the severity of the symptoms. Current understanding of neurobiological visual processing and research in diseases with reduced cholinergic function, suggests that AChEI-s may prove beneficial in treating visual hallucinations. This offers the potential for targeted drug therapy of clinically symptomatic visual hallucinations in patients with schizophrenia using acetylcholinesterase inhibition.

MethodsA systematic review was carried out investigating the evidence for the effects of AChEI-s in treating visual hallucinations in Schizophrenia.

ResultsNo evidence was found relating to the specific role of AChEI-s in treating visual hallucinations in this patient group.

DiscussionGiven the use of AChEI-s in targeted, symptom specific treatment in other neuropsychiatric disorders, it is surprising to find no related literature in schizophrenia patients. The use of AChEI-s in schizophrenia has investigated effects on cognition primarily with non cognitive effects measured more broadly.

ConclusionsWe would suggest that more focused research into the effects of AChEI-s on positive symptoms of schizophrenia, specifically visual hallucinations, is needed.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-244X-10-69 contains supplementary material, which is available to authorized users.

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Autor: Sachin S Patel - Azizah Attard - Pamela Jacobsen - Sukhi Shergill

Fuente: https://link.springer.com/







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