Previous hospital admissions and disease severity predict the use of antipsychotic combination treatment in patients with schizophreniaReportar como inadecuado




Previous hospital admissions and disease severity predict the use of antipsychotic combination treatment in patients with schizophrenia - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Psychiatry

, 11:126

First Online: 03 August 2011Received: 10 September 2010Accepted: 03 August 2011

Abstract

BackgroundAlthough not recommended in treatment guidelines, previous studies have shown a frequent use of more than one antipsychotic agent among patients with schizophrenia. The main aims of the present study were to explore the antipsychotic treatment regimen among patients with schizophrenia in a catchment area-based sample and to investigate clinical characteristics associated with antipsychotic combination treatment.

MethodsThe study included 329 patients diagnosed with schizophrenia using antipsychotic medication. Patients were recruited from all psychiatric hospitals in Oslo. Diagnoses were obtained by use of the Structured Clinical Interview for DSM-IV Axis I disorders SCID-I. Additionally, Global Assessment of Functioning GAF, Positive and Negative Syndrome Scale PANSS and number of hospitalisations and pharmacological treatment were assessed.

ResultsMultiple hospital admissions, low GAF scores and high PANSS scores, were significantly associated with the prescription of combination treatment with two or more antipsychotics. The use of combination treatment increased significantly from the second hospital admission. Combination therapy was not significantly associated with age or gender. Regression models confirmed that an increasing number of hospital admission was the strongest predictor of the use of two or more antipsychotics.

ConclusionsPrevious hospital admissions and disease severity measured by high PANSS scores and low GAF scores, predict the use of antipsychotic combination treatment in patients with schizophrenia. Future studies should further explore the use of antipsychotic drug treatment in clinical practice and partly based on such data establish more robust treatment guidelines for patients with persistently high symptom load.

AbbreviationsDDDDefined Daily Doses

FGAFirst Generation Antipsychotic

SGASecond Generation Antipsychotics

GAF-FGlobal Assessment of Functioning

SCID-IThe Structured Clinical Interview for DSM-IV

PANSSPositive and Negative Syndrome Scale

DUPDuration of Untreated Psychosis

TOPThematically Organized Psychosis

Download fulltext PDF



Autor: Albert Bolstad - Ole A Andreassen - Jan I Røssberg - Ingrid Agartz - Ingrid Melle - Lars Tanum

Fuente: https://link.springer.com/



DESCARGAR PDF




Documentos relacionados