The thyroid function of Graves disease patients is aggravated by depressive personality during antithyroid drug treatmentReportar como inadecuado

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BioPsychoSocial Medicine

, 5:9

First Online: 09 August 2011Received: 06 May 2011Accepted: 09 August 2011


BackgroundWe previously reported that depressive personality the scores of hypochondriasis, depression and psychasthenia determined by the Minnesota Multiphasic Personality Inventory MMPI and daily hassles of Graves- disease GD patients treated long trem with antithyroid drug ATD were significantly higher in a relapsed group than in a remitted group, even in the euthyroid state. The present study aims to examine the relationship among depressive personality, emotional stresses, thyroid function and the prognosis of hyperthyroidism in newly diagnosed GD patients.

MethodsSixty-four untreated GD patients responded to the MMPI for personality traits, the Natsume-s Stress Inventory for major life events, and the Hayashi-s Daily Life Stress Inventory for daily life stresses before and during ATD treatment.

ResultsIn the untreated thyrotoxic state, depressive personality T-scores of hypochondriasis, depression or psychasthenia greater than 60 points in MMPI were found for 44 patients 69%. For 15 23% of these patients, the scores decreased to the normal range after treatment. However, depressive personality persisted after treatment in the remaining 29 patients 46%. Normal scores before treatment were found for 20 patients 31%, and the scores were persistently normal for 15 patients 23%. The remaining 5 patients 8% had higher depressive personality after treatment. Such depressive personality was not associated with the severity of hyperthyroidism. Serum TSH receptor antibody activity at three years after treatment was significantly p = 0.0351 greater in the depression group than in the non- depression group. The remission rate at four years after treatment was significantly p = 0.0305 lower in the depression group than in the non- depression group 22% vs 52%.

ConclusionThe data indicate that in GD patients treated with ATD, depressive personality during treatment reflects the effect of emotional stress more than that of thyrotoxicosis and that it aggravates hyperthyroidism. Psychosomatic therapeutic approaches including antipsychiatric drugs and-or psychotherapy appears to be useful for improving the prognosis of hyperthyroidism.

Electronic supplementary materialThe online version of this article doi:10.1186-1751-0759-5-9 contains supplementary material, which is available to authorized users.

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Autor: Atsushi Fukao - Junta Takamatsu - Sumihisa Kubota - Akira Miyauchi - Toshiaki Hanafusa


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