Olanzapine is superior to lamotrigine in the prevention of bipolar depression: a naturalistic observational studyReportar como inadecuado

Olanzapine is superior to lamotrigine in the prevention of bipolar depression: a naturalistic observational study - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Psychiatry

, 14:145

Mood disorders


BackgroundBipolar disorder is a highly recurrent disease and has great impact on the function of patients. Depressive symptoms consist of more than 50% of life time during the illness and may lead to self harm or suicidal behaviors. Little is known about the antidepressant effects of olanzapine, an atypical antipsychotic, as monotherapy despite its indication for preventing manic episodes. In contrast, lamotrigine, a mood stabilizer, has been proven to be effective in preventing depression in patients with bipolar disorder. However, no studies have compared the efficacy between lamotrigine and olanzapine in the maintenance treatment of bipolar disorder. This enriched naturalistic study was implemented to assess the effectiveness of olanzapine and lamotrigine as monotherapy in the prevention of recurrence of bipolar disorder.

MethodsPatients with bipolar disorder in a euthymic state Young’s Mania Rating Scale YMRS score <12, and 21-item Hamilton Depression Rating Scale HAM-D score <7 for at least two months, having already received either olanzapine or lamotrigine as the maintenance treatment were recruited. The patients maintained with olanzapine n = 22 were applied to olanzapine group whereas those maintained with lamotrigine n = 29 were applied to lamotrigine group. They were followed up for 12 months. Differences in the efficacy between olanzapine and lamotrigine in recurrence prevention were analyzed. The Kaplan-Meier method was used to generate time-to-recurrence curves, and differences between the two groups were compared using the log-rank test.

ResultsOlanzapine had a significantly lower recurrence rate of depressive episodes than lamotrigine 20.0% vs. 57.7%, χ = 6.62, p = .010. However, olanzapine and lamotrigine had similar mania 15.0% vs. 0%, χ = 4.17, p = .075, Fisher’s exact test and any mood episode 35.0% vs. 57.7%, χ = 2.33, p = .127 recurrence rates. Olanzapine was significantly superior to lamotrigine in the time to recurrence of depressive episodes χ = 4.55, df = 1, p = .033, but there was no difference in the time to recurrence of any mood episode χ = 1.68, df = 1, p = .195.

ConclusionsThis prospective naturalistic study suggests that olanzapine is more effective than lamotrigine in the prevention of depressive episodes in patients with bipolar disorder. Future large-scale randomized studies are warranted to validate our results.

Trial registrationClinicalTrials.gov ID NCT01864551.

KeywordsOlanzapine Lamotrigine Bipolar disorder Maintenance treatment Electronic supplementary materialThe online version of this article doi:10.1186-1471-244X-14-145 contains supplementary material, which is available to authorized users.

Download fulltext PDF

Autor: Pei-Yin Pan - Meei-Shyuan Lee - Miao-Chi Lo - En-Lin Yang - Chin-Bin Yeh

Fuente: https://link.springer.com/

Documentos relacionados