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R. de Cássia Gonçalves Alfenas ;Nutrición Hospitalaria 2012, 27 2

Autor: A. P. Boroni Moreira

Fuente: http://www.redalyc.org/articulo.oa?id=309226786007


Introducción



Nutrición Hospitalaria ISSN: 0212-1611 info@nutriciónhospitalaria.com Grupo Aula Médica España Boroni Moreira, A.
P.; de Cássia Gonçalves Alfenas, R. The influence of endotoxemia on the molecular mechanisms of insulin resistance Nutrición Hospitalaria, vol.
27, núm.
2, marzo-abril, 2012, pp.
382-390 Grupo Aula Médica Madrid, España Available in: http:--www.redalyc.org-articulo.oa?id=309226786007 How to cite Complete issue More information about this article Journals homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative Nutr Hosp.
2012;27(2):382-390 ISSN 0212-1611 • CODEN NUHOEQ S.V.R.
318 Revisión The influence of endotoxemia on the molecular mechanisms of insulin resistance A.
P.
Boroni Moreira1 and R.
de Cássia Gonçalves Alfenas2 1 Candidate for doctoral degree in Nutrition Science.
Federal University of Viçosa.
Minas Gerais.
Brazil.
2Assistant Professor. Nutrition and Health Department.
Federal University of Viçosa.
Brazil. Abstract Introduction: The reduction in the capacity of insulin to reach its biological effects can lead to a chronic hyperglycemia and hyperinsulinemia, assuming an important role in the pathogenesis of metabolic disorders associated to obesity and diabetes.
Insulin resistance is associated to chronic subclinical inflammation, which in part can be mediated by increased plasmatic lipopolysaccharide levels, an endotoxin derived from the membrane of gramnegative bacteria that mainly reside in the gut. Objectives: The aim of this review study is to describe the molecular mechanisms involved in the pathogenesis of insulin resistance due to metabolic endotoxemia and of its connection to obesity and diabetes. Results and discussion: Lipopolysaccharide present in the intestinal lumen can reach the circulatory system causing metabolic endotoxemia.
When lipopolysaccharide...





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