Various Terpenoids Derived from Herbal and Dietary Plants Function as PPAR Modulators and Regulate Carbohydrate and Lipid MetabolismReportar como inadecuado

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PPAR ResearchVolume 2010 2010, Article ID 483958, 9 pages

Review Article

Department of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Gifu 501-1193, Japan

Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji 611-0011, Japan

Laboratory of Food Nutrition, Division of Applied Biological Chemistry, Graduate School of Horticulture, Chiba University, 648 Matsudo, Chiba 271-8510, Japan

Received 8 February 2010; Accepted 23 March 2010

Academic Editor: Harry Martin

Copyright © 2010 Tsuyoshi Goto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Several herbal plants improve medical conditions. Such plants contain many bioactive phytochemicals. Terpenoids also called “isoprenoids” constitute one of the largest families of natural products accounting for more than 40,000 individual compounds of both primary and secondary metabolisms. In particular, terpenoids are contained in many herbal plants, and several terpenoids have been shown to be available for pharmaceutical applications, for example, artemisinin and taxol as malaria and cancer medicines, respectively. Various terpenoids are contained in many plants for not only herbal use but also dietary use. In this paper, we describe several bioactive terpenoids contained in herbal or dietary plants, which can modulate the activities of ligand-dependent transcription factors, namely, peroxisome proliferator-activated receptors PPARs. Because PPARs are dietary lipid sensors that control energy homeostasis, daily eating of these terpenoids might be useful for the management for obesity-induced metabolic disorders, such as type 2 diabetes, hyperlipidemia, insulin resistance, and cardiovascular diseases.

Autor: Tsuyoshi Goto, Nobuyuki Takahashi, Shizuka Hirai, and Teruo Kawada



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