Is the BCG Vaccine Safe for Undernourished IndividualsReportar como inadecuado




Is the BCG Vaccine Safe for Undernourished Individuals - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Clinical and Developmental ImmunologyVolume 2012 2012, Article ID 673186, 6 pages

Research ArticleDepartamento de Microbiologia e Imunologia, Instituto de Biociências, Universidade Estadual Paulista UNESP, 18618-970 Botucatu, SP, Brazil

Received 8 December 2011; Accepted 11 February 2012

Academic Editor: Enrico Maggi

Copyright © 2012 Larissa Lumi Watanabe Ishikawa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cellular immunity is critical for protection against tuberculosis, but its integrity is compromised during undernutrition. The present study was designed to evaluate if the attenuated mycobacterium BCG is a safe vaccine for undernourished individuals. An experimental model of undernutrition was established by subjecting BALB-c mice to dietary restriction. These animals received 70% of the amount of food consumed by the healthy control group and exhibited physiological alterations compatible with malnutrition, including body weight loss, reduced levels of triglycerides and glucose, and reduced lymphocyte numbers. Undernourished mice were immunized with BCG, and the mycobacterial loads in lymph nodes, spleen, liver, lungs, and thymus were determined. A much higher proportion of undernourished mice exhibited bacterial dissemination to the lymph nodes, spleen and liver. In addition, only undernourished animals had bacteria in the lungs and thymus. Concomitant with higher mycobacterial loads and more widespread BCG dissemination in undernourished mice, production of TNF-α, IFN-γ, and IL-10 was also diminished in these mice. Taken together, these results indicate that BCG infection is more severe in undernourished mice. Whether a similar phenomenon exists in undernourished children or not remains to be thoroughly investigated.





Autor: Larissa Lumi Watanabe Ishikawa, Larissa Camargo da Rosa, Thais Graziela Donegá França, Raphael Sanches Peres, Fernanda Chius

Fuente: https://www.hindawi.com/



DESCARGAR PDF




Documentos relacionados