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BMC Psychiatry

, 16:42

Psychotic disorders

Abstract

BackgroundCurrent practice guidelines for schizophrenia care recommend that antipsychotic medication is essential for patients’ long-term maintenance treatment but their non-adherence to this medication is still a main obstacle to relapse prevention. This study evaluated the effects of a motivational-interviewing-based adherence therapy for people with schizophrenia spectrum disorders.

MethodsThis randomised controlled trial was conducted with 134 outpatients with schizophrenia spectrum disorders; 67 of them received a six-session adherence therapy in addition to usual care and 67 received usual psychiatric care alone. Participants’ outcome measures included symptom severity, medication adherence, hospitalisation rates, insight into illness-treatment, and functioning.

ResultsThe adherence therapy group reported significantly greater improvements in symptom severity p < 0.003, insight into illness-treatment p < 0.001, functioning p < 0.005, duration of re-hospitalisations p < 0.005, and medication adherence p < 0.005 over 18 months follow-up, when compared with usual care alone.

ConclusionsMotivational-interviewing-based adherence therapy can be an effective approach to treatment for people with early stage of schizophrenia who poorly adhere to medication regimen.

Trial registrationClinicalTrials.gov NCT01780116, registration date January 29, 2013.

KeywordsAdherence therapy Antipsychotics Randomised controlled trial Motivational interviewing Schizophrenia Insight into treatment AbbreviationsARSAdherence Rating Scale

ATAdherence Therapy

CONSORTConsolidated Standards of Reporting Trials

CPNSCommunity Psychiatric Nursing Service

CPNcommunity psychiatric nurse

DAIDrug Attitude Inventory

ITAQInsight and Treatment Attitudes Questionnaire

PANSSPositive and Negative Syndrome Scale

SLOFSpecific Level of Functioning Scale TAU, Treatment as usual

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Autor: Wai Tong Chien - Jolene Mui - Richard Gray - Eric Cheung

Fuente: https://link.springer.com/







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