Clinical features, course and treatment of methamphetamine-induced psychosis in psychiatric inpatientsReportar como inadecuado

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BMC Psychiatry

, 16:44

Substance-related disorders, addiction and impulse control


BackgroundOver the past few years, methamphetamine-induced psychosis MIP has increased in Iran, accounting for a significant percentage of psychiatry hospital admissions. The present study was conducted with an aim to investigate clinical symptoms, and course and treatment methods of MIP inpatients in Shafa Psychiatry Hospital in northern Iran.

MethodsParticipants were 152 MIP inpatients. Brief Psychiatric Rating Scale BPRS subscales of suspiciousness, unusual thought content; hallucinations and hostility were used to measure psychiatric symptoms. Data regarding suicide and homicide and violence were also obtained through interviews with the inpatients and their family. Based on their lengths of recovery time, the inpatients were categorized into 3 clinical groups. These inpatients received their usual treatments and were monitored for their psychiatric symptoms and clinical course of illness. The data were analyzed by descriptive statistics.

ResultsThe most frequent psychiatric symptoms were violence 75.6 %, intimate partner violence 61.2 %, delusions of persecution 85.5 %, delusions of reference 38.5 %, delusions of grandiosity 32.9 %, delusions of infidelity 30.2 %, auditory hallucinations 51.3 %, visual hallucinations 18.4 %, suicidal thoughts 14.5 %, homicidal thoughts 3.9 %, suicide attempts 10.5 % and homicide attempts 0.7 %. Recovery from psychotic symptoms in 31.6 % of the inpatients took more than one month. 46.1% of the inpatients were treated with Risperidone and 37.5 % with Olanzapine. Persecutory delusion and auditory hallucination were the most frequent persistent psychotic symptoms. 20.8 % of the inpatients with duration of psychosis more than one month were treated with electroconvulsive therapy ECT along with antipsychotics.

ConclusionAll forms of violence are highly frequent in MIP inpatients. Our finding agrees with many other studies suggesting that recovery from MIP can take more than a month. Initial promising findings were found regarding the efficacy of Electroconvulsive therapy in MIP patients.

KeywordsMethamphetamine Psychotic disorders Inpatients Violence AbbreviationsIPVIntimate partner violence

MIPMethamphetamine induced psychosis

ECTElectroconvulsive therapy

BPRSBrief psychiatric rating scale

DSMIV-TRDiagnostic and statistical manual of mental disorders. 4th edition. Text revision

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Autor: Homa Zarrabi - Mohammadrasoul Khalkhali - Azam Hamidi - Reza Ahmadi - Maryam Zavarmousavi


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