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BioMed Research International - Volume 2014 2014, Article ID 548392, 7 pages -

Research Article

Department of Medical Imaging, First Affiliated Hospital of Medical College of Xi’an Jiaotong University, Xi’an 710061, China

Medical Imaging Centre, An Kang Central Hospital, 85-Jinzhou South Road, AnKang 725000, China

The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China

Received 18 December 2013; Accepted 14 January 2014; Published 20 February 2014

Academic Editor: Lin Ai

Copyright © 2014 Yanan Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Previous studies reported discrepant white matter diffusivity in mild traumatic brain injury mTBI on the base of Glasgow Coma Scale, which are unreliable for some TBI severity indicators and the frequency of missing documentation in the medical record. In the present study, we adopted the Mayo classification system for TBI severity. In this system, the mTBI is also divided into two groups as “probable and symptomatic” TBI. We aimed to investigate altered microstructural integrity in symptomatic acute TBI <1 week by using tract-based spatial statics TBSS approach. A total of 12 patients and 13 healthy volunteers were involved and underwent MRI scans including conventional scan, and SWI and DTI. All the patients had no visible lesions by using conventional and SWI neuroimaging techniques, while showing widespread declines in the fractional anisotropy FA of gray matter and white matter throughout the TBSS skeleton, particularly in the limbic-subcortical structures. By contrast, symptomatic TBI patients showed no significant enhanced changes in FA compared to the healthy controls. A better understanding of the acute changes occurring following symptomatic TBI may increase our understanding of neuroplasticity and continuing degenerative change, which, in turn, may facilitate advances in management and intervention.

Autor: Yanan Zhu, Zhengjun Li, Lijun Bai, Yin Tao, Chuanzhu Sun, Min Li, Longmei Zheng, Bao Zhu, Jun Yao, Heping Zhou, and Ming

Fuente: https://www.hindawi.com/


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