Lambda-prophage induction modeled as a cooperative failure mode of lytic repression - Quantitative Biology > Molecular NetworksReportar como inadecuado




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Abstract: We analyze a system-level model for lytic repression of lambda-phage in E.coli using reliability theory, showing that the repressor circuit comprises 4redundant components whose failure mode is prophage induction. Our modelreflects the specific biochemical mechanisms involved in regulation, includinglong-range cooperative binding, and its detailed predictions for prophageinduction in E. coli under ultra-violet radiation are in good agreement withexperimental data.



Autor: Nicholas Chia, Ido Golding, Nigel Goldenfeld

Fuente: https://arxiv.org/







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