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BioMed Research International - Volume 2015 2015, Article ID 324815, 13 pages -

Review ArticleDepartment of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University, Universiteitssingel 50, P.O. Box 616, 6200 MD Maastricht, Netherlands

Received 29 August 2014; Revised 12 December 2014; Accepted 12 December 2014

Academic Editor: Wen-Hwa Lee

Copyright © 2015 Sophie E. van der Krieken et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The prevalence of the metabolic syndrome and underlying metabolic disturbances increase rapidly in developed countries. Various molecular targets are currently under investigation to unravel the molecular mechanisms that cause these disturbances. This is done in attempt to counter or prevent the negative health consequences of the metabolic disturbances. Here, we reviewed the current knowledge on the role of C-EBP-β in these metabolic disturbances. C-EBP-β deletion in mice resulted in downregulation of hepatic lipogenic genes and increased expression of β-oxidation genes in brown adipose tissue. Furthermore, C-EBP-β is important in the differentiation and maturation of adipocytes and is increased during ER stress and proinflammatory conditions. So far, studies were only conducted in animals and in cell systems. The results found that C-EBP-β is an important transcription factor within the metabolic disturbances of the metabolic system. Therefore, it is interesting to examine the potential role of C-EBP-β at molecular and physiological level in humans.

Autor: Sophie E. van der Krieken, Herman E. Popeijus, Ronald P. Mensink, and Jogchum Plat



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