Synthesis and Evaluation of Novel Pyrroles and Pyrrolopyrimidines as Anti-Hyperglycemic AgentsReportar como inadecuado




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BioMed Research International - Volume 2014 2014, Article ID 249780, 13 pages -

Research Article

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ein-Helwan, Helwan, Cairo 11795, Egypt

Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Helwan University, Ein-Helwan, Helwan, Cairo 11795, Egypt

Received 12 February 2014; Revised 16 May 2014; Accepted 22 May 2014; Published 26 June 2014

Academic Editor: Paul M. Tulkens

Copyright © 2014 M. S. Mohamed et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A series of pyrrole and pyrrolopyrimidine derivatives were examined for their in vivo antihyperglycemic activity. Compounds Ia–c,e, and IVg showed promising antihyperglycemic activity equivalent to a well-known standard antihyperglycemic drug, Glimepiride Amaryl, 4 mg-kg. In this paper, we examine and discuss the structure-activity relationships and antihyperglycemic activity of these compounds.





Autor: M. S. Mohamed, S. A. Ali, D. H. A. Abdelaziz, and Samar S. Fathallah

Fuente: https://www.hindawi.com/



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