Lack of evidence for a genetic association between FGF20 and Parkinsons disease in Finnish and Greek patientsReportar como inadecuado




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BMC Neurology

, 5:11

First Online: 20 June 2005Received: 06 April 2005Accepted: 20 June 2005

Abstract

BackgroundFibroblast growth factor 20 FGF20 is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic association has been found between FGF20 gene and the risk of suffering from Parkinson-s disease PD. Our aim was to replicate this association in two independent populations.

MethodsAllelic, genotypic, and haplotype frequencies of four biallelic polymorphisms were assessed in 151 sporadic PD cases and 186 controls from Greece, and 144 sporadic PD patients and 135 controls from Finland.

ResultsNo association was found in any of the populations studied.

ConclusionTaken together, these findings suggest that common genetic variants in FGF20 are not a risk factor for PD in, at least, some European populations.

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Autor: Jordi Clarimon - Georgia Xiromerisiou - Johanna Eerola - Vanesa Gourbali - Olli Hellström - Euthimios Dardiotis - Terhi Pe

Fuente: https://link.springer.com/



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