Efficacy of the epidural blood patch for the treatment of post lumbar puncture headache BLOPP: A randomised, observer-blind, controlled clinical trial ISRCTN 71598245Reportar como inadecuado




Efficacy of the epidural blood patch for the treatment of post lumbar puncture headache BLOPP: A randomised, observer-blind, controlled clinical trial ISRCTN 71598245 - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Neurology

, 5:12

First Online: 05 July 2005Received: 27 May 2005Accepted: 05 July 2005

Abstract

BackgroundPost dural punction headache PDPH occurs in 10% to 40% of the patients who had a lumbar puncture. Its symptoms can be severe and incapacitating. The epidural blood patch is widely accepted as the treatment of choice for postdural puncture headache. Uncontrolled studies report rapid recovery after patching in 90% to 100% of treated patients. However, sufficient evidence from randomised, controlled clinical trials is lacking.

MethodsBLOPP blood patch for post dural puncture headache is a randomised, single centre, observer-blind clinical trial. Patients with PDPH for at least 24 hours and at most 7 days after lumbar puncture will be randomised to treatment with an epidural blood patch EDBP or to conventional treatment, i.e. 24 hours bed rest and ample fluid intake. PDPH 24 hours after treatment, classified on a 4-point scale no, mild, moderate, severe is the primary outcome. The secondary outcome is the presence of PDPH 7 days after treatment. We estimated that a sample size of 2 × 20 patients would provide us with a power of 80% to detect a relative reduction in number of patients with persisting PDPH after 24 hours of 50% at the usual significance level α = 5%, taking into account that in approximately 10% of the patients the PDPH will have resolved spontaneously after one day.

DiscussionThe EDBP is accepted as the treatment of choice for PDPH although randomised, controlled data is scarce. Our randomised, observer-blind clinical trial enables us to compare the efficacy of two clinically practiced methods of PDPH treatment; EDBP versus conventional treatment, as they are applied in clinical practise.

List of abbreviationsCSFCerebrospinal fluid

EDBPEpidural blood patch

PDPHPost dural punction headache

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2377-5-12 contains supplementary material, which is available to authorized users.

R Oedit, F van Kooten, SLM Bakker and DWJ Dippel contributed equally to this work.

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Autor: R Oedit - F van Kooten - SLM Bakker - DWJ Dippel

Fuente: https://link.springer.com/



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