Observations on comatose survivors of cardiopulmonary resuscitation with generalized myoclonusReportar como inadecuado




Observations on comatose survivors of cardiopulmonary resuscitation with generalized myoclonus - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

BMC Neurology

, 5:14

First Online: 18 July 2005Received: 30 March 2005Accepted: 18 July 2005

Abstract

BackgroundThere is only limited data on improvements of critical medical care is resulting in a better outcome of comatose survivors of cardiopulmonary resuscitation CPR with generalized myoclonus. There is also a paucity of data on the temporal dynamics of electroenephalographic EEG abnormalities in these patients.

MethodsSerial EEG examinations were done in 50 comatose survivors of CPR with generalized myoclonus seen over an 8 years period.

ResultsGeneralized myoclonus occurred within 24 hours after CPR. It was associated with burst-suppression EEG n = 42, continuous generalized epileptiform discharges n = 5, alpha-coma-EEG n = 52, and low amplitude 10 μV < recording n = 1. Except in 3 patients, these EEG-patterns were followed by another of these always nonreactive patterns within one day, mainly alpha-coma-EEG n = 10 and continuous generalized epileptiform discharges n = 9. Serial recordings disclosed a variety of EEG-sequences composed of these EEG-patterns, finally leading to isoelectric or flat recordings. Forty-five patients died within 2 weeks, 5 patients survived and remained in a permanent vegetative state.

ConclusionGeneralized myoclonus in comatose survivors of CPR still implies a poor outcome despite advances in critical care medicine. Anticonvulsive drugs are usually ineffective. All postanoxic EEG-patterns are transient and followed by a variety of EEG sequences composed of different EEG patterns, each of which is recognized as an unfavourable sign. Different EEG-patterns in anoxic encephalopathy may reflect different forms of neocortical dysfunction, which occur at different stages of a dynamic process finally leading to severe neuronal loss.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2377-5-14 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Autor: Frank Thömke - Jürgen J Marx - Oliver Sauer - Thomas Hundsberger - Stefan Hägele - Jascha Wiechelt - Sacha L Weilemann

Fuente: https://link.springer.com/







Documentos relacionados