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BioMed Research International - Volume 2015 2015, Article ID 249740, 8 pages -

Review Article

-Carol Davila- University of Medicine and Pharmacy, Dionisie Lupu Street No. 37, District 1, 022328 Bucharest, Romania

Center of Internal Medicine-Nephrology, Fundeni Clinical Institute, 258 Fundeni Street, District 2, 022328 Bucharest, Romania

Center for Uronephrology and Renal Transplantation, Fundeni Clinical Institute, 258 Fundeni Street, District 2, 022328 Bucharest, Romania

-Dr. Carol Davila- Teaching Hospital of Nephrology, Calea Grivitei Street No. 4, District 1, 010731 Bucharest, Romania

Received 2 June 2015; Revised 19 September 2015; Accepted 30 September 2015

Academic Editor: Jennifer Pluznick

Copyright © 2015 Bogdan Obrisca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Since the identification of PLA2R M-type phospholipase A2 receptor as the first human antigenic target in primary membranous nephropathy MN, perpetual progress has been made in understanding the pathogenesis of this disease. Accumulating clinical data support a pathogenic role for the anti-PLA2R antibodies PLA2R ABs, but confirmation in an animal model is still lacking. However, PLA2R ABs were related to disease activity and outcome, as well as to response therapy. Accordingly, PLA2R ABs assay seems to be promising tool not only to diagnose MN but also to predict the course of the disease and could open the way to personalize therapy. Nevertheless, validation of a universal assay with high precision and definition of cut-off levels, followed by larger studies with a prolonged follow-up period, are needed to confirm these prospects.





Autor: Bogdan Obrisca, Gener Ismail, Roxana Jurubita, Catalin Baston, Andreea Andronesi, and Gabriel Mircescu

Fuente: https://www.hindawi.com/



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