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BMC Neurology

, 5:15

First Online: 24 August 2005Received: 25 February 2005Accepted: 24 August 2005


BackgroundParkinsonian symptoms have been associated with increased morbidity and mortality. Several studies have reported on the prevalence of signs and symptoms. Symptoms questionnaires can identify potential PD cases for further neurological examination to save resources. They can also provide information about how much of the population reports specific signs and symptoms. The objective of the study was to determine the self-reported prevalence of parkinsonian symptoms from a questionnaire, and to examine their association with age and self-reported Parkinson-s disease in a large cohort.

MethodsA cross-sectional study was conducted within a sub-cohort of the EPIC-Norfolk European Prospective Investigation of Cancer cohort study.

ResultsThe prevalence of six self-reported parkinsonian symptoms are reported for 11539 individuals who answered all symptoms questions 62% of sub-cohort: rest tremor 4%, difficulty starting to walk 4%, difficulty getting out of a chair 6%, slower walking 34%, smaller handwriting micrographia- 9%, and less acute sense of smell olfactory dysfunction- 9%. The presence of individual symptoms increased with age except for difficulty getting out of a chair.

ConclusionThe results support previous findings that the presence of self-reported parkinsonian symptoms is strongly associated with age and self-reported PD diagnosis. The data also provide information regarding the prevalence of symptoms in a large, younger population of adults than previously reported in the literature.

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Autor: Lianna S Ishihara - Kay-Tee Khaw - Robert Luben - Sheila Bingham - Ailsa Welch - Nicholas Day - Carol Brayne


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