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Borderline Personality Disorder and Emotion Dysregulation

, 4:13

First Online: 05 July 2017Received: 18 January 2017Accepted: 24 April 2017


BackgroundDialectical behavioral therapy DBT skills have become increasingly used to treat several psychiatric conditions, including major depressive disorder MDD. The aim of the study was to investigate the efficacy of an intervention that combines emotion regulation and mindfulness skills of DBT to prevent depression relapse-recurrence.

MethodsA total of 75 individuals 79% females; mean age, 52 years with a diagnosis of MDD in complete or partial remission were recruited. Participants were randomly allocated either to an intervention combining emotion regulation and mindfulness skills ER + M group, n = 37 or to a psychoeducative program n = 38. After the 10-week treatment period, participants were followed for 1 year. Analyses were run in per-protocol PP and intention-to-treat ITT samples. The primary outcome measure was time to depression relapse-recurrence.

ResultsER + M training was not more effective than the control intervention in preventing depression relapse. However, PP and ITT analyses showed that participants trained in ER + M presented a significant reduction in depressive symptoms and overall psychopathology. Based on the PP and ITT analyses, neither of the interventions were related with an increase in dispositional mindfulness.

ConclusionsMore studies are needed to confirm the efficacy of ER + M to decrease depressive symptoms and overall psychopathology.

Trial registrationNCT02747134. Registered on 20 April 2016.

KeywordsMindfulness Emotion regulation Major depression Relapse Recurrence AbbreviationsAMAntidepressant medication

BABehavioral activation

BDIBeck Depression Inventory

CBTCognitive Behavioral Therapy

DBTDialectical Behavioral Therapy

DSM-IV-TRDiagnostic Interview for Mental Disorders Fourth Edition Text Revised

EREmotion regulation

HDSRHamilton Depression Rating Scale

ITTIntention To Treat


MAASMindful Attention Awareness Scale MAAS

MBCTMindfulness Based Cognitive Therapy

MDDMajor Depressive Disorder

OAOpposite action

PPPer Protocol

SCID-IStructural clinical interview for DSM-IV

SCL-90-GSISymptom Checklist 90 General Severity Index

TAUTreatment as usual

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Autor: Matilde Elices - Joaquim Soler - Albert Feliu-Soler - Cristina Carmona - Thais Tiana - Juan C. Pascual - Azucena García-P


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