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Child and Adolescent Psychiatry and Mental Health

, 11:30

First Online: 05 July 2017Received: 07 September 2016Accepted: 22 May 2017


BackgroundThe prevalence of mood disorders in children is a growing global concern. Omega-3 fatty acids FA are emerging as a promising adjuvant therapy for depressive disorder DD in paediatric patients. The primary objective of this pilot, single-centre, randomized, double-blind controlled study was to compare the efficacy of an Omega-3 FA fish oil emulsion with a control oil emulsion alongside standard treatment for depressive symptoms in children and adolescents suffering from depressive disorder DD and mixed anxiety depressive disorder MADD.

Methods38 children 12 patients were treated and diagnosed for at least 1 month before enrolment, 26 patients were first-time diagnosed as DD aged 11–17 years were randomised 1:1 to the intervention Omega-3 FA, 19 patients or active comparator Omega-6 FA, 19 patients groups. Children’s depression inventory CDI ratings were performed at baseline, every 2 weeks for a 12-week intervention period and at 4-week post-intervention. 35 patients 17 in Omega-3 and 18 in Omega-6 groups who completed the whole intervention period were evaluated. Patients from Omega-3 group were stratified according to diagnosis into two subgroups DD—10-17 and mixed anxiety depressive disorder MADD—7-17 patients and in the Omega-6 group into DD—10-18 and MADD—8-18 patients. Groups were evaluated separately. Differences between-groups were tested with the Students t test or non-parametric Mann–Whitney U test. Two-way ANOVA with repeated measures and Friedman test were used to analyse the Treatment effect for response in CDI score. p < 0.05 was considered significant in all statistical analyses.

ResultsSignificant reductions in CDI scores in 35 analysed patients who completed 12 weeks intervention were observed after 12 weeks of intervention only in the Omega-3 group p = 0.034. After stratification to depressive disorder and mixed anxiety depressive disorder subgroups, the DD subgroup receiving the Omega-3 FA fish oil showed statistically greater improvement score reduction after 8 week treatment of −9.1 CDI, p = 0.0001 when compared to the MADD subgroup score reduction after 8 week treatment −4.24 CDI, p = 0.271.

ConclusionsCDI scores were reduced in the Omega-3 group and the depression subgroup had greater improvement than the mixed depressive-anxiety group. An Omega-3 fatty acid rich fish oil emulsion may be an effective adjuvant supplement during the treatment of depressive disorders in children.

Trial registration ISRCTN81655012

AbbreviationsCDIchildren’s depression inventory

CDRSchildren’s depression rating scale

DDdepressive disorder

DHAdocosahexaenoic acid

EPAeicosapentaenoic acid


FAfatty acids

ICDinternational classification of diseases


MADDmixed anxiety depression disorder

Plevel of statistical significance

SDstandard deviation

SEstandard error

SSRIselective serotonin reuptake inhibitor

Electronic supplementary materialThe online version of this article doi:10.1186-s13034-017-0167-2 contains supplementary material, which is available to authorized users.

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Autor: Jana Trebatická - Zuzana Hradečná - František Böhmer - Magdaléna Vaváková - Iveta Waczulíková - Iveta Garaiova - J

Fuente: https://link.springer.com/

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