Latent profile analysis in frontotemporal lobar degeneration and related disorders: clinical presentation and SPECT functional correlatesReportar como inadecuado

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BMC Neurology

, 7:9

First Online: 16 May 2007Received: 16 September 2006Accepted: 16 May 2007


BackgroundFrontotemporal Lobar Degeneration FTLD thus recently renamed, refers to a spectrum of heterogeneous conditions. This same heterogeneity of presentation represents the major methodological limit for the correct evaluation of clinical designation and brain functional correlates. At present, no study has investigated clinical clusters due to specific cognitive and behavioural disturbances beyond current clinical criteria.

The aim of this study was to identify clinical FTLD presentation, based on cognitive and behavioural profile, and to define their SPECT functional correlations.

MethodsNinety-seven FTLD patients entered the study. A clinical evaluation and standardised assessment were preformed, as well as a brain SPECT perfusion imaging study. Latent Profile Analysis on clinical, neuropsychological, and behavioural data was performed. Voxel-basis analysis of SPECT data was computed.

ResultsThree specific clusters were identified and named -pseudomanic behaviour- LC1 -cognitive- LC2, and -pseudodepressed behaviour- LC3 endophenotypes. These endophenotypes showed a comparable hypoperfusion in left temporal lobe, but a specific pattern involving: medial and orbitobasal frontal cortex in LC1, subcortical brain region in LC2, and right dorsolateral frontal cortex and insula in LC3.

ConclusionThese findings provide evidence that specific functional-cluster symptom relationship can be delineated in FTLD patients by a standardised assessment. The understanding of the different functional correlates of clinical presentations will hopefully lead to the possibility of individuating diagnostic and treatment algorithms.

AbbreviationsFTLDFrontotemporal Lobar Degeneration

SPECTSingle Photon Emission Tomography

bvFTDbehavioural variant of frontotemporal dementia

SDSemantic Dementia

PNFAProgressive Non-fluent Aphasia

PSPProgressive Supranuclear Palsy

CBDCorticobasal Degeneration

LPALatent Profile Analysis.

Electronic supplementary materialThe online version of this article doi:10.1186-1471-2377-7-9 contains supplementary material, which is available to authorized users.

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Autor: Barbara Borroni - Mario Grassi - Chiara Agosti - Barbara Paghera - Antonella Alberici - Monica Di Luca - Daniela Perani - A


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